Foreign
Collaborators:
Several investigators
from USA and European universities are currently collaborating
in some of our research projects: Drs. Robert H. Young, Harvard
University, Boston, Victor Reuter, Memorial Sloan Kettering
Cancer Center and Cornell University, New York, Mahul Amin,
Emory University, and, Alberto Ayala and Pheroze Tamboli, MD
Anderson Cancer Hospital, Houston, Texas, Mark Rubin, University
of Michigan, Allan Hildesheim, Epidemiology Branch, National
Cancer Institute, Bethesda Maryland, Robert Kurman, John Hopkins
University.
From
Europe: Holger Moch, University of Basel, Switzerland,
Chris Meijer, Free University of Amsterdam, Netherland, Xavier
Matias, Hospital San Pau, Barcelona, Spain, Juan Rosai, Istituto
Tumori Milan, Italy.
Areas
of research interest:
The majority of the studies are centered on Cancer of the Penis,
but other areas of interest are female genital cancers, polyps
and colonic cancers in Paraguay, and unusual thyroid tumors.
Penile cancer studies
Penile cancer is particularly frequent in Paraguay. We have
examined pathologic materials from about 800 patients with the
disease. Investigations are mainly morphological, although epidemiological,
clinical and molecular studies are also performed.
Anatomical
studies: Transforming the classical cadaveric
into a more vivid surgical pathology oriented anatomy we designed
a system of examining and handling the penile resected specimen
with cancer emphasizing the normal anatomical levels in the
various epithelial compartments. We found 3 distinct anatomical
levels in the glans that when invaded by tumor correlate with
prognosis. Foreskin studies preputial variability…….A
new study in the foreskin is being conducted with a predictable
similar outcome.
Titles
of recent studies presented in the United States Canadian Academy
of Pathology (USCAP) and published as Abstracts in Laboratory
Investigation or in Modern Pathology (1999, 2000, 2001,2002,
2003, 2004)
Epithelial lesions associated with invasive SCC of the penis.
Lab Invest 79:88A, 1999.
Prognostic
parameters in SCC of the penis. Lab Invest 79: 104A, 1999.
Secondary Tumors
of the penis. A study of 16 cases. Lab Invest 79: 104A,1999.
Cytokeratin
subset distribution in histologic variants of SCC of the penis.
Lab Invest 79: 92A, 1999.
Histologic
classification, regional metastasis and outcome in 61 patients
with primary resection of penile carcinoma Lab Invest 79: 92A,
1999.
Verruciform
tumors of the penis. Histologic classification of 68 cases.
Lab Invest 79: 109A, 1999.
Prognostic
Index: a novel method to predict mortality in SCC of the penis.
Lab Invest 80: 97A, 2000.
Geographical
comparison of subtypes of penile SCC from regions of low and
high incidence. Lab Invest 80: 97A, 2000.
Gene expression
analysis of genital SCC using the tumor tissue array technology.
Lab Invest 80: 108A.,2000
Anatomical
levels: landmarks in penectomy specimens. Lab Invest 80:11A,
2000.
Detection of
HPV in penile condyloma ,dysplasia and invasive carcinoma using
a novel line probe assay for rapid detection and simultaneous
identification of 25 HPV types. Lab Invest 80: 113A, 2000.
Mixed basaloid-warty
(condylomatous) SCC of the penis. A report of 17 cases. Lab
Invest 80: 115A, 2000.
Basaloid SCC
of the penis. A clinico pathologic study of 11 cases. Lab Invest
80: 117A, 2000.
Seudohyperplastic
superficial SCC of the foreskin associated with lichen sclerosus.
A distinctive clinico pathologic entity. A report of 10 cases.
Mod Path 14: 105A, 2001.
Continuous
sequence of Squamous Hyperplasia and invasive SCC of the penis
suggest a causal link. Mod Path 14: 120A, 2001.
High grade
Squamous Intraepithelial Lesion of the penis: morphologic subtypes
correlate with homologous variants of invasive SCC. A report
of 126 cases. Mod Path 14: 126A, 2001.
Correlation
of Lichen Sclerosus with histological types of SCC of the penis.
A study of 61 cases. Mod Path 14: 127A, 2001.ç
Coexisting
benign condyloma and SCC of the penis: preferential association
with the warty and basaloid variants. Report of 21 cases. Mod
Path 14: 127A, 2001.
Correlation
of HPV detection with P53, P27 and Ki 67 protein expression
in penile carcinoma using tissue microarray technology. Mod
Path 14: 131A, 2001.
Squamous cell
Carcinoma exclusive of the foreskin: distinctive association
with low grade variants, multicentricity and lichen sclerosus.
Mod Path 15: 175A, 2002.
Preferential
association of penile carcinoma with long foreskin and phimosis:
an anatomical copmparative study of types of foreskin in a general
population and cancer patients. Mod Path 15: 186A, 2002.
Urethral epithelial
abnormalities in patients with invasive Squamous cell carcinoma
of the penis. Mod Path 16: 146A, 2003.
The inter relationship
among subtypes of precancerous lesions and invasive neoplasms
of the penis indicate heterogeneous pathways of cancer progression.
Mod Path 16: 146A, 2003.
Positive resection
margins in penectomies for penile carcinoma: sites of involvement
in 14 cases. Mod Path 16: 175A, 2003.
Problems and
limitations in the interpretation of biopsies in patients with
penile squamous cell carcinoma. Mod Path 16: 175A, 2003.
Autopsy findings
in 14 patients with penile Squamous cell carcinoma. Mod Path
17: 5A, 2004.
Carcinoma cuniculatum
of the penis: a distinctive deeply invasive variant of verrucous
carcinoma. Mod Path 17: 140A, 2004.
The heterogeneous
spectrum of penile verrucous carcinoma: morphological features
of classical types and mixed variants.A report of 36 cases.
Mod Path 17: 146A, 2004.
Sarcomatoid
carcinoma of the penis. A clinicopathologic study of 14 cases,
Mod Path 17: 183A, 2004.
Comparison
of morphological features and outcome of resected primary and
recurrent Squamous cell carcinoma of the penis. Mod Path 17:
184A, 2004.
Other published
and non published studies Many other papers on penile and colon
cancer has been published in local journals in spanish, which
are not listed in the major international scientific indexes.
Projects previously presented at the USCAP meetings are either
published, in process of preparation for publication or in press.
A new line of clinical and molecular research have been established
in the area of neoplastic lesions of the foreskin.
